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Bitter Sophora Root Extract

Date:2019-04-28    Views:376
Product Description
bitter sophora flavescens extract

Bitter Sophora Root contains about a dozen alkaloids, with matrine and oxymatrine being by far the highest, together comprising about 2% of the dried root stock (most of it in the form of oxymatrine), followed by closely related alkaloids: mainly sophocarpine, but also minute amounts of sophoranol, sophoramine, sophoridine, allomatrine, isomatrine, and others. These alkaloids were first reported as constituents of kushen in a series of publications from 1958-1978.An overview of recent research on the pharmacology and clinical applications of the sophora alkaloids is presented below. In general, the dosage of the sophora alkaloids administered clinically is in the range of 400-600 mg per day.

Specification

Product Name: Bitter Sophora Root Extract
Latin Name: Sophora flavescens
Plant part used: Root
Active Ingredient: Matrine, Oxymatrine
Specification: Matrine 1%,10%,20%,90%,98%
Oxymatrine 98%
Test Method: HPLC
Extract Method: Grain Alcohol/Water
Appearance: White Fine Powder

bitter sophora flavescens extract

Matrine

CAS: 519-02-8

Molecular Formula: C15H24N2O

Molecular Weight: 248.36

Description:

An alkaloid extracted from the chinese sophora herb plants; has a relatively low toxicity; demonstrated antiviral and anti-inflammatory bioactivity; shows to induce apoptosis in many human cancer cell lines

Oxymatrine

CAS: 16837-52-8

Molecular Formula: C15H24N2O2

Molecular Weight 264.36

Description:

Oxymatrine is a quinolizidine alkaloid extracted from the root of Sophora flavescens, which is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases.

bitter sophora flavescens extract
ITEMS
Limits/Specification
Test Method
Results
Matrine
≥98.0%
HPLC
98.2%
Appearance
White Crystalline powder
Visual
Complied
Odor / Taste
Characteristic
Organoleptic
Complied
Mesh Size
100% Pass 80 mesh
80 Mesh Screen
Complied
Loss on drying
≤5.0%
CP2015
3.12%
Ash Content
≤0.1%
CP2015
0.06%
Specific Rotation
+31°~+36°
CP2015
+34°
Heavy metals
≤20ppm
CP2015
Complied
Arsenic (As)
≤2.0ppm
CP2015
Complied
Lead (Pb)
≤2.0ppm
CP2015
Complied
Cadmium (Cd)
≤1.0ppm
CP2015
Complied
Mercury (Hg)
≤1.0ppm
CP2015
Complied
Solvent residences
Negative
UPS32<563>
Complied
Pesticide Residue
Eur.Pharm.
Eur.Pharm.
Complied
Total Plate Count
≤1000 cfu/g
GB/T4789.27-2003
350cfu/g
Yeast and Mold
≤100 cfu/g
GB/T4789.15-2003
44cfu/g
E. Coli
Negative
GB/T4789-2003
Negative
Salmonella
Negative
GB/T4789-2003
Negative

Matrine and oxymatrine are the two major alkaloid components found in bitter sophora root. They are obtained primarily from Sophora japonica (kushen), but also from Sophora subprostrata (shandougen), and from the above ground portion of Sophora alopecuroides. An intensive investigation into the pharmacology and clinical applications of these alkaloids has gone on for the past decade and remains one of the focal points of Chinese medical research. The main clinical applications of bitter sophora root extract are treatment of people with cancer, viral hepatitis, cardiac diseases, and skin diseases.

Product Detailed
bitter sophora flavescens extract
bitter sophora flavescens extract
Function
1.Matrine is widely used in pesticide;
2.Matrine has function of relieving internal heat;
3.Matrine has effect on anti-bacteria, anti-inflammatory;
4.Matrine is used for suppressing sarcoma S180, anti-tumors;
5.Matrine can cure tonsillitis, mastitis, smooth the asthma etc. when taken orally;
6.Matrine can improve the leucocyte deficiency symptoms so as to enhance the body's immune function;
7. Matrine is effective in dealing with trichomonad vaginitis, flagellate disease, amoeba dysentery and fungus dysentery, etc.

Application

1.Applied in Pharmaceutical as capsules or pills;
2.Applied in Functional food & Health products as capsules or pills;
3.Applied in Food Industry: Water-soluble beverages;
4.Applied in Cosmetics field.
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