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2019 Blueberry Leaf- the King of Berries (2)What is the Applications of Blueberry Leaf?

Date:2019-03-07    Views:173

In the last article, we shared with everyone what are blueberry leaves? Then in today's article we will continue to share with you the " fantastic function" of blueberry leaves.

Everyone may know that chlorogenic acid is the active ingredient in blueberry leaves. What is chlorogenic acid as the main ingredient? What does it do? After reading this article, you will definitely get something!

Chlorogenic acid has a wide range of biological activities. Modern scientific research on the biological activities of chlorogenic acid has gone deep into many fields such as food, health care, medicine and daily chemical industry. Chlorogenic acid is an important bioactive substance with antibacterial, antiviral, leukocyte increasing, liver protecting, gallbladder benefiting, antitumor, blood pressure lowering, blood lipid lowering, free radical scavenging, and central nervous system excitation effects.

·Antibacterial and antiviral

Chlorogenic acid from Eucommia ulmoides Oliv. has strong antibacterial and anti-inflammatory effects. aucubin and its polymers have obvious antibacterial effects. aucubin has inhibitory effects on gram-negative and positive bacteria. Aucubin has antibacterial and diuretic effects, and can promote wound healing. After preculture with glucoside, aucubin also has obvious antiviral effect, but it does not have antiviral function. Research by the Jialing Institute of Medical Sciences of Aichi Medical University in Japan has confirmed that the alkaline substance extracted from Eucommia ulmoides Oliv. has the function of resisting viruses damaging human immune system, and this substance may be used for preventing and treating AIDS.


Chlorogenic acid is an effective phenolic antioxidant, and its antioxidant capacity is stronger than caffeic acid, p - hydroxybenzoic acid, ferulic acid, syringic acid, butyl hydroxy anisole ( BHA ) and tocopherol. Chlorogenic acid has antioxidant effect because it contains a certain amount of R-OH groups, which can form hydrogen radicals with antioxidant effect to eliminate the activities of hydroxyl radicals and superoxide anions and other free radicals, thus protecting tissues from oxidative damage.

·Scavenging free radicals, anti - aging, anti - musculoskeletal aging

Chlorogenic acid and its derivatives have stronger radical scavenging effects than ascorbic acid, caffeic acid and tocopherol ( vitamin E ), can effectively scavenge DPPH radical, hydroxyl radical and superoxide anion radical, and can also inhibit oxidation of low density lipoprotein. Chlorogenic acid plays an important role in effectively eliminating free radicals in the body, maintaining the normal structure and function of cells in the body, preventing and delaying the occurrence of tumor mutation and aging. Chlorogenic acid from Eucommia ulmoides contains a special component that can promote the synthesis and decomposition of mucin in human skin, bones and muscles. It has the functions of promoting metabolism and preventing decline. It can be used to prevent the decline of bones and muscles caused by weightlessness in space. At the same time, chlorogenic acid from Eucommia ulmoides is found to have obvious anti-free radical effect both in vivo and in vitro.

·Inhibiting Mutation and Antitumor

Modern pharmacological experiments have proved that chlorogenic acid from Eucommia ulmoides Oliv. has anti-cancer and anti-cancer effects. Japanese scholars have studied the antimutagenicity of chlorogenic acid from Eucommia ulmoides Oliv. and found that the antimutagenicity is related to chlorogenic acid and other antimutagenicity components, revealing the important significance of chlorogenic acid in tumor prevention.

Polyphenols such as chlorogenic acid and caffeic acid in vegetables and fruits can inhibit the mutagenicity of carcinogens aflatoxin B1 and benzo [a]- pyrene by inhibiting activating enzymes. Chlorogenic acid can also reduce the utilization rate of carcinogens and their transport in the liver to achieve the effects of cancer prevention and anticancer. Chlorogenic acid has significant inhibitory effect on colorectal cancer, liver cancer and laryngeal cancer, and is considered as an effective chemical protective agent for cancer.

·Protective effect on cardiovascular system

As a free radical scavenger and antioxidant, chlorogenic acid has been proved by a large number of experiments that this biological activity of chlorogenic acid can produce protective effect on cardiovascular system. Isochlorogenic acid B has a strong effect on promoting the release of prostacyclin ( PGI2 ) and anti-platelet aggregation in rats. The inhibition rate of SRS-A release induced by antibody induced to guinea pig lung fragments was 62.3%. Isochlorogenic acid C can also promote PGI2 release. In addition, isochlorogenic acid B has a strong inhibitory effect on the biosynthesis of thromboxane and endothelin injury not induced by hydrogen peroxide.

·Hypotensive effect

Many years of clinical tests have proved that chlorogenic acid from Eucommia ulmoides Oliv. has obvious antihypertensive effect, stable curative effect, no toxicity and no side effects. A study by the University of Wisconsin found that the effective components for lowering blood pressure in Eucommia ulmoides green are pinitol diglucoside, aucubin, chlorogenic acid, and Eucommia ulmoides chlorogenic acid polysaccharide.

·Other biological activities

Chlorogenic acid has a special inhibitory effect on hyaluronic acid ( HAase ) and glucose - 6 - phosphatase ( Gl-6-Pase ), so chlorogenic acid has certain curative effects on wound healing, healthy and moist skin, lubrication of joints, prevention of inflammation and balance regulation of blood sugar in vivo. Chlorogenic acid has strong inhibitory and killing effects on various diseases and viruses. Chlorogenic acid has pharmacological effects of lowering blood pressure, resisting bacteria, resisting virus, diminishing inflammation, increasing white blood cells, preventing diabetes, obviously increasing gastrointestinal peristalsis and promoting gastric juice secretion, and has obvious curative effect on acute throat inflammation. Studies have shown that oral administration of chlorogenic acid can significantly stimulate bile secretion and has the effects of promoting bile flow and protecting liver. It can also effectively inhibit hemolysis of rat erythrocytes caused by H2O2.

The effect of chlorogenic acid can be said to be very comprehensive. As the effective ingredient of blueberry leaves, we can also better use it according to needs.

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