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Broccoli, one of the familiar vegetables in a daily diet, is known as the crown of vegetable. The study of the University of Gothenburg in Sweden has pushed the broccoli boom to the peak again. In addition to anti-cancer, anti-depression, liver protection, intestinal protection, etc., researchers have explored the potential role of broccoli extract in type 2 diabetes. The antioxidant sulforaphane contained in broccoli extract is a new type of anti-diabetic ingredient. Studies have shown that sulforaphane can significantly lower blood sugar levels, and it can be used as an auxiliary method for existing drug treatment in the future.
The study aimed to find new ways to fight against type 2 diabetes, the mechanism of action of which is mainly the increase in glucose in the liver. The mechanism of action of traditional drugs such as metformin is to reduce the endogenous glucose production in the liver, improve the sensitivity of the liver to insulin, and reduce the decomposition of glycogen to exert hypoglycemic effects.
However, it can cause side effects in the stomach and is not suitable for people with impaired renal function. According to the planting media, the mechanism of action of sulforaphane in lowering blood sugar is mainly achieved by inhibiting the enzyme that stimulates glucose production in the liver.
In the study, the researchers mapped the genetic changes of diabetic patients and found that 50 genes play an important role. The researchers then compared the gene signatures of thousands of active ingredients associated with these key genes to find compounds that are specifically associated with gene expression in hepatocytes. The researchers used computer mathematical analysis to evaluate 2,800 active substances and found that sulforaphane has strong application characteristics and has a strong influence on diabetes-related gene expression. Previous studies have confirmed that sulforaphane can be used to treat cancer and inflammatory diseases, but its preventive effect on diabetes has not been found.
The researchers conducted animal studies to test cells in diet-induced diabetic mice and found that radish for 4 weeks reduced blood sugar by 23%, while metformin reduced blood sugar by 24%. In light of the results of cell and animal experiments, the researchers conducted related clinical trials. The researchers recruited approximately 100 Type 2 diabetic subjects who were essentially using metformin. The researchers asked the subjects to take sulforaphane every morning for 12 weeks. The study found that compared with the placebo group, the blood glucose control in the experimental group was lower and the BMI (one of the potential factors for elevated blood glucose) was significantly lower in the blood glucose levels of 30 and above.
A patient study was then conducted on approximately 100 patients. All people are receiving metformin, but in the 12 weeks of the group taking sulfur phosphorus every morning, patients with lower glycemic control and patients with BMI of 30 or higher (known as associated with elevated blood glucose) Factors) blood glucose levels were significantly lower than in the placebo group. In other words, in the study, 17 patients increased glucose levels in the liver.
However, the concentration of sulforaphane used in the study was about 100 times that of broccoli, meaning that four to five kilograms of broccoli were consumed each day, an effect that seems unlikely to be achieved by eating broccoli. The researchers point out that broccoli can be made into a powder that can be added to food or drinks, and they plan to start working on functional foods within two years. As a functional food, it is more easily recognized by the majority of consumers, convenient to use, but also has a certain market appeal.
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