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Anti - oxidation fuction
Active oxygen means a class of oxygenates that are directly or indirectly converted. A class of oxygenates with more reactive chemical reactivity than molecular oxygen. Under normal circumstances, the body can maintain ROS within a certain range, but when affected by inflammation, chemical agents, radiation, etc., the balance is broken and ROS continues to rise. Excessive ROS can cause damage to DNA, liposomes, proteins, etc., leading to diseases such as malignant tumors.
The anti-oxidant effect of Luteolin is mainly manifested in the oxidation reaction of its own as a reducing agent, and the enhancement of the activity of the antioxidant system of the living body.
Luteolin itself can be used as an antioxidant because it has the basic structure of the antioxidant activity of flavonoids. There are two hydroxyl groups at the 3' and 4' positions, a carbon-carbon double bond between the 2 and 3 positions, and a carbonyl group at the 4 position. Because the hydroxyl of the aromatic compound easily provides a hydrogen atom to the radical, so the Luteolin having the above structural characteristics has strong reducibility and can be used as a hydrogen donor to reduction radicals. The most direct demonstration of Luteolin itself as an antioxidant is direct antioxidant in a cell-free system. For example, DPPH analysis indicates that Luteolin concentration-dependent inhibits the activity of DPPH free radicals.
Luteolin can also enhance the activity of the antioxidant enzyme system in Biological body. Ruban et al. In vitro induce the rat's crystal-like lesions
by selenite and observed the effect of Luteolin in reactive oxygen species in the lens. Research has found that selenite significantly reduces the activity of superoxide dismutase (SOD) and catalase (CAT), but Luteolin improves this change and restores SOD and CAT activity. Research of Ashokkumar and Sudhandiran also found that oxidized azomethane significantly inhibited the activity of SOD and CAT in colon tissue, and the activity of both was significantly increased after the use of Luteolin. Small molecular substances in the body, such as vitamins A, C, and E, are also involved in scavenging oxygen free radicals and are an indispensable part of the body's antioxidant system. Luteolin can increase the content of Vitamin A, Vitamin C, and Vitamin E and improve the oxidative damage caused by oxidized azomethane to colon tissue. In addition, Luteolin can also increase the activity by glutathione peroxidase (GPx) and glutathione reductase (GR) and to increase the content of reduced glutathione play an anti-oxidation role.
Luteolin as a natural flavonoid has its own antioxidant effect. Adding antioxidant foods, cosmetics, health products, Luteolin will be a good choice.
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